Staff
段亚君
发布时间：2018-09-11 阅读次数: 25
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个人学习工作简介
段亚君教授是国家优秀青年科学基金获得者，黄山青年学者。2004年毕业于南开大学生物科学专业，获得学士学位；2009 年毕业于南开大学生物化学与分子生物学专业，获得博士学位。
近五年发表通讯或共同通讯作者论文20篇，共同第一作者论文2篇，其中包括：在动脉粥样硬化领域权威期刊之一ATVB发表2篇论文；在经典期刊Journal of Biological Chemistry (JBC)发表论文6篇；在Int J Cancer发表论文1篇、Biochem J发表论文2篇、BBA-Mol Basis Dis发表论文1篇、BBA-Mol Cell Biol Lipid发表论文2篇、授权发明专利1项。
近五年发表通讯或共同通讯作者论文20篇，共同第一作者论文2篇，其中包括：在动脉粥样硬化领域权威期刊之一ATVB发表2篇论文；在经典期刊Journal of Biological Chemistry (JBC)发表论文6篇；在Int J Cancer发表论文1篇、Biochem J发表论文2篇、BBA-Mol Basis Dis发表论文1篇、BBA-Mol Cell Biol Lipid发表论文2篇、授权发明专利1项。
主要研究领域与方向
重大慢病防治研究：硕士招生方向为生物化学与分子生物学、制药工程；博士招生方向为食品科学；欢迎推免和报考！
代表性研究成果
发现巨噬细胞泡沫化调控的新机制，防治动脉粥样硬化的新靶点，发表SCI论文三十余篇。
目前承担科研项目
Ø 主持国家自然科学基金优秀青年科学基金: 巨噬细胞在动脉粥样硬化中的作用和机制研究，2018.1-2020.12，直接经费130万元。
Ø 主持国家自然科学基金面上项目: MEK1/2抑制剂协同肝X受体激动剂促进动脉粥样硬化斑块稳定与消退，2016.1-2019.12，直接经费65万元。
Ø 另承担国际合作项目子课题、黄山青年学者项目等，经费约140万元。
Ø 主持国家自然科学基金面上项目: MEK1/2抑制剂协同肝X受体激动剂促进动脉粥样硬化斑块稳定与消退，2016.1-2019.12，直接经费65万元。
Ø 另承担国际合作项目子课题、黄山青年学者项目等，经费约140万元。
获奖情况
中国脂质与脂蛋白专业委员会青年委员，多次获得会议论文奖励、博士在读期间获得国家留学基金委建设高水平大学项目资助。
著作论文（代表作）
1. Sun L, Yang X, Li Q, Zeng P, Liu Y, Liu L, Chen Y, Yu M, Ma C, Li X, Li Y, Zhang R, Zhu Y, Miao QR, Han J*, Duan Y*. Activation of Adiponectin Receptor Regulates Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Inhibits Lesions in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1290-1300.
2. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y*, Han J*. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1180-91.
3. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*.Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89. （封面论文）
4. Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice. Sci Rep. 2016 Jun 2;6:27295.
5. Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Duan Y*. Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE. J Biol Chem. 2016 Jul 15;291(29):15108-18.
6. Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y*, Chen Y*. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochem Biophys Res Commun. 2016 May 13;473(4):939-946.
7. Liu M, Zhang W, Li X, Han J, Chen Y*, Duan Y*. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochem Biophys Res Commun. 2016 Jan 15;469(3):456-62.
8. Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake. J Biol Chem. 2015 Sep 4;290(36):21788-99.
9. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Sci Rep. 2015 Jun 10;5:11219.
10. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y*, Han J*. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29.
11. Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of Pitavastatin and Dexamethasone Exacerbates the High-fat Diet-induced Atherosclerosis in apoE-deficient Mice. J Cardiovasc Pharmacol. 2015 Aug;66(2):189-95.
12. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice. Evid Based Complement Alternat Med. 2015;2015:242517.
13. Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao RQ, Xiang R, Hajjar DP, Han J. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):948-59.
14. Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. Biochim Biophys Acta. 2015 May;1852(5):1038-48.
15. Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. Int J Cancer. 2015 Feb 15;136(4):771-83. （封面论文）
16. Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice. J Cardiovasc Pharmacol. 2014 May;63(5):441-52.
17. Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin. 2014;59:1366-1373.
18. Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*. Identification of interferon-γ as a new molecular target of liver X receptor. Biochem J. 2014 Apr 15;459(2):345-54. （Commentary: Biochemical Journal. 2014;459:e1-e3, 专评论文）
19. Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways. Biochem J. 2013 Sep 15;454(3):467-77.
20. Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochim Biophys Acta. 2013 Jun;1831(6):1134-45.
21. Chen Y, Duan Y*, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. J Biol Chem. 2012 Dec 21;287(52):43340-50.
22. Duan Y#, Chen Y#, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem. 2012 Jul 6;287(28):23667-77.
23. Zhang J#, Duan Y#, Wei D, Wang L, Wang H, Gu Z, Kong D. Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery. J Biomed Mater Res A. 2011 Jan;96(1):212-20.
24. Duan Y#, Yang C#, Zhang Z, Liu J, Zheng J, Kong D. Poly(ethylene glycol)-grafted polyethylenimine modified with G250 monoclonal antibody for tumor gene therapy. Hum Gene Ther. 2010 Feb;21(2):191-8.
25. Duan Y, Yang C, Zhang Z, Liu J, Zheng J, Xu Y, Kong D, Yu Y. Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth. Chinese Science Bulletin. 2009;54: 2947-52.
26. Duan Y, Zheng J, Han S, Wu Y, Wang Y, Li D, Kong D, Yu Y. A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy. J Control Release. 2008 Apr 21;127(2):173-9.
2. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, Li L, Miao QR, Hajjar DP, Duan Y*, Han J*. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1180-91.
3. Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, Li X, Li Y, Duan S, Han J*, Duan Y*.Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)γ-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89. （封面论文）
4. Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J*, Duan Y*. Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice. Sci Rep. 2016 Jun 2;6:27295.
5. Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J*, Duan Y*. Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ) and CD36 Protein Expression: THE DUAL PATHOPHYSIOLOGICAL ROLES OF PROGESTERONE. J Biol Chem. 2016 Jul 15;291(29):15108-18.
6. Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y*, Chen Y*. MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes. Biochem Biophys Res Commun. 2016 May 13;473(4):939-946.
7. Liu M, Zhang W, Li X, Han J, Chen Y*, Duan Y*. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochem Biophys Res Commun. 2016 Jan 15;469(3):456-62.
8. Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J*, Duan Y*. Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake. J Biol Chem. 2015 Sep 4;290(36):21788-99.
9. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Sci Rep. 2015 Jun 10;5:11219.
10. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y*, Han J*. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29.
11. Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of Pitavastatin and Dexamethasone Exacerbates the High-fat Diet-induced Atherosclerosis in apoE-deficient Mice. J Cardiovasc Pharmacol. 2015 Aug;66(2):189-95.
12. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X*, Duan Y*. NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice. Evid Based Complement Alternat Med. 2015;2015:242517.
13. Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao RQ, Xiang R, Hajjar DP, Han J. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):948-59.
14. Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y*, Han J*. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. Biochim Biophys Acta. 2015 May;1852(5):1038-48.
15. Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y*, Han J*. Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production. Int J Cancer. 2015 Feb 15;136(4):771-83. （封面论文）
16. Chen Y, Liu M, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y*. Danhong injection inhibits the development of atherosclerosis in both Apoe⁻/⁻ and Ldlr⁻/⁻ mice. J Cardiovasc Pharmacol. 2014 May;63(5):441-52.
17. Liu M, Chen Y, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y*. Danhong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin. 2014;59:1366-1373.
18. Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y*, Han J*. Identification of interferon-γ as a new molecular target of liver X receptor. Biochem J. 2014 Apr 15;459(2):345-54. （Commentary: Biochemical Journal. 2014;459:e1-e3, 专评论文）
19. Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y*, Han J*. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways. Biochem J. 2013 Sep 15;454(3):467-77.
20. Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y*, Han J*. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism. Biochim Biophys Acta. 2013 Jun;1831(6):1134-45.
21. Chen Y, Duan Y*, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J*. Activation of liver X receptor induces macrophage interleukin-5 expression. J Biol Chem. 2012 Dec 21;287(52):43340-50.
22. Duan Y#, Chen Y#, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. J Biol Chem. 2012 Jul 6;287(28):23667-77.
23. Zhang J#, Duan Y#, Wei D, Wang L, Wang H, Gu Z, Kong D. Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery. J Biomed Mater Res A. 2011 Jan;96(1):212-20.
24. Duan Y#, Yang C#, Zhang Z, Liu J, Zheng J, Kong D. Poly(ethylene glycol)-grafted polyethylenimine modified with G250 monoclonal antibody for tumor gene therapy. Hum Gene Ther. 2010 Feb;21(2):191-8.
25. Duan Y, Yang C, Zhang Z, Liu J, Zheng J, Xu Y, Kong D, Yu Y. Non-viral gene carrier mediated short hairpin RNA interference for inhibition of tumor cells growth. Chinese Science Bulletin. 2009;54: 2947-52.
26. Duan Y, Zheng J, Han S, Wu Y, Wang Y, Li D, Kong D, Yu Y. A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy. J Control Release. 2008 Apr 21;127(2):173-9.
